pentobarbital will decrease the level or effect of artemether/lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration with sturdy CYP3A4 inducers can lead to lessened serum concentrations and loss of antimalarial efficacyPentobarbital functions inside the CNS by binding to gamma-aminobuty